I just came across a wonderful blog post by Steve Blank (friend sent it to me).  It is basically about what the title of this post says.  Great to read, and it includes a 180 page slide deck that is superb.  It could serve as a road map for many of us.

See it here:  http://steveblank.com/2011/03/18/new-rules-for-the-new-bubble/

Enjoy.